Non-Coding
RNA-Mediated
Regulatory Networks
Non-Coding
RNA-Mediated
Regulatory Networks
At ncRNA-lab we are interested in deciphering the regulatory pathways mediated by non coding RNAs (mainly small ncRNAs) for a better understanding of the molecular mechanisms that allow crops to respond and eventually adapt to biotic and abiotic stress conditions.
Research lines
Regulatory networks of response to stress mediated by miRNAs
In general, plants respond to changes in environmental conditions through a complex transcriptional reprogramming…
miRNAs are fundamental endogenous regulators of gene expression in higher organisms. miRNAs modulate multiple biological processes…
Viroids-host interactions
Viroids are a class of sub-viral plant-pathogenic long noncoding RNAs (240-400 nt) composed of a circular single-stranded molecule. Viroid infection comprises a series of coordinated steps involving…
Eukaryotic organisms exposed to adverse conditions are required to show a certain degree of transcriptional plasticity in order…
News
The Department of Innovation funds our BotVid-Sensor project for early detection of a fungus causing severe losses in grapevines.
The Generalitat Valenciana, through the Department of Innovation, Industry, Trade, and Tourism, finances our BotVid-Sensor project for the development of an early and low-cost alert system to...
Congratulations on the Acceptance of Our New Manuscript on sRNA Alterations in SARS-CoV-2 Response
We are pleased to share a noteworthy update from our research team: our manuscript examining sRNA changes in response to SARS-CoV-2 infection has been accepted for publication in Nature NPJ Systems...
Welcome María Carmen Marqués to Our Laboratory Team!
We are thrilled to extend a warm welcome to our newest team member, María Carmen Marqués! As ncRNA Lab, we pride ourselves on fostering an environment of collaboration, innovation, and excellence,...
Members
Faculty
Gustavo Germán Gómez
CSIC Scientific Researcher
gustavo.gomez@csic.es
Tel: (+34) 963544777
+ info
Gustavo Germán Gómez
CSIC Scientific Researcher
(+34) 963544777
gustavo.gomez@csic.es
+ info
Postdoctoral Researchers
Francesca Longo
Plant-PREDICTOR Project
francesca.longo@csic.es
Tel: (+34) 963543996
+ info
María Carmen Herranz Gordo
BotVid-SENSOR Project
mc.herranz@csic.es
Tel: (+34) 963543996
+ info
María Carmen Marqués Romero
PreDeSTom Project
mc.marques@csic.es
Tel: (+34) 963543996
+ info
PhD Students
Julia Corell Sierra
Predoctoral contract, GVA (ACIF)
julia.corell@csic.es
Tel: (+34) 963544783
+ info
Predoctoral contract, GVA (ACIF)
gabriela.hernandez@csic.es
Tel: (+34) 963544783
+ info
Pascual Villalba Bermell
Predoctoral contract, AEI
pascual.villalba@csic.es
Tel: (+34) 963544783
+ info
Antonio González Sánchez
Predoctoral contract
antonio.gonzalez.sanchez@csic.es
Tel: (+34) 963544783
+ info
Samanta Gissela Silva Valencia
Predoctoral contract, GVA (GRISOLÍA)
samanta.silva@csic.es
Tel: (+34) 963544783
+ info
Miguel Ruiz Ibáñez
Predoctoral contract
m.ruiz.ibanez@csic.es
Tel: (+34) 963544783
+ info
Marta Núñez Salvador
Predoctoral contract
marta.nunez@csic.es
Tel: (+34) 963544783
+ info
Technical assistant
Vega Tirado Guardia
Lab technician
vega.tirado@csic.es
Tel: (+34) 963543996
+ info
Students
Javier Lozano
TFM IBMCG UV
Tel: 34 963543996
Elisa Soriano
TFG Biotechnology UCV
Tel: 34 963543996
Projects
Current projects
Global-REPaIr
The objective of this project is to understand the molecular basis of the plant-environment interactions at global scale in economically important crops.
PreDeSTom
The objective of this Project is the “Development of a dual strategy for the mitigation of the damage associated to stress, in tomato…
BotVidSENSOR
The objective of the project BotVidSENSOR, is the development of a tool for the diagnosis of the «grey rot» disease, caused by B. cinerea, which allow the EARLY monitoring…
Plant Predictor
Stress-induced changes in plants (including those produced by pests or pathogens) are usually detected by the appearance of visual symptoms, usually once the adverse effects on crop…
EGReNMel
Environmental stresses (largely facilitated by climate change) limit the productive potential of many agricultural species. Faced with adverse environmental…
Global-REPaIr
The objective of this project is to understand the molecular basis of the plant-environment interactions at global scale in economically important crops.
PreDeSTom
The objective of this Project is the “Development of a dual strategy for the mitigation of the damage associated to stress, in tomato…
BotVidSENSOR
The objective of the project BotVidSENSOR, is the development of a tool for the diagnosis of the «grey rot» disease, caused by B. cinerea, which allow the EARLY monitoring…
Plant Predictor
Stress-induced changes in plants (including those produced by pests or pathogens) are usually detected by the appearance of visual symptoms, usually once the adverse effects on crop…
EGReNMel
Environmental stresses (largely facilitated by climate change) limit the productive potential of many agricultural species. Faced with adverse environmental…
Past projects
COV-CRISPIS
Traditional viral infection diagnostic techniques in the clinic are based on (RT-)PCR procedures, which are time consuming and require precise equipment…
Funct. Validation of sncRNA
As consequence of the exposition to stress-inductors plants trigger a complex regulatory response that results in adaptation to adverse conditions. In general…
COV-CRISPIS
Traditional viral infection diagnostic techniques in the clinic are based on (RT-)PCR procedures, which are time consuming and require precise equipment…
Funct. Validation of sncRNA
As consequence of the exposition to stress-inductors plants trigger a complex regulatory response that results in adaptation to adverse conditions. In general…
Projects
Current projects
Past projects
Publications
Relevant Publications
(last ten years)
Márquez-Molins, J., Villalba-Bermell, P., Corell-Sierra, J., Pallás, V. & Gomez, G. (2023) Integrative time scale and multi omics analysis of host responses to Viroid infection. Plant, Cell & Environment, 1–19. DOI: 10.1111/pce.14647.
Márquez-Molins J, Juarez-Gonzalez VT, Gomez G, Pallas V, Martinez G. (2022). Occurrence of RNA post-transcriptional modifications in plant viruses and viroids and their correlation with structural and functional features. Virus Res. DOI: 10.1016/j.virusres.2022.198958.
Marquez-Molins J., Hernandez-Azurdia A.G., Urrutia-Perez M., Pallas V. and Gomez G. (2022). A circular RNA vector for targeted plant gene silencing based on an asymptomatic viroid. The Plant Journal. DOI: 10.1111/tpj.15929.
Gómez G., Marquez-Molins J., Martinez G. and Pallas V. (2022) Plant epigenome alterations: an emergent player in viroid-host interactions. Virus Res. 318:198844. DOI: 10.1016/j.virusres.2022.198844.
Marqués MC., Sánchez-Vicente J., Ruiz R., Montagud-Martínez R., Márquez-Costa R., Gómez G., Carbonell A., Daròs JA. and Rodrigo G. (2022) Diagnostics of Infections Produced by the Plant Viruses TMV, TEV, and PVX with CRISPR-Cas12 and CRISPR-Cas13. ACS Synth Biol. DOI: 10.1021/acssynbio.2c00090.
Villalba-Bermell P., Marquez-Molins J., Marques MC., Corell-Sierra J., Hernandez-Azurdia AG., Pico B., Monforte AJ., Elena SF., Gomez G. (2021) Combined stress conditions in melon induce non-additive effects in the core miRNA regulatory network. Front. Plant Sci. 12:769093. DOI: 10.3389/fpls.2021.769093
Marquez-Molins J, Navarro JA, Seco LC, Pallas V, Gomez G. (2021) Might exogenous circular RNAs act as protein-coding transcripts in plants? RNA Biol. 14:1-10. DOI: 10.1080/15476286.2021.1962670
Vázquez-Prol F, Márquez-Molins J, López-Gresa MP, Bellés JM, Gomez G, Pallás V, Lisón P. (2021) Symptom Severity, Infection Progression and Plant Responses in Solanum Plants Caused by Three Pospiviroids… Int. J. Mol. Sci. 22: 6189. DOI: 10.3390/ijms2212618
Marquez-Molins, J., Gomez G., Pallas V. (2020) Hop stunt viroid: a polyphagous pathogenic RNA that has shed light on viroid-host interactions. Mol. Plant. Pathology. DOI: 10.1111/mpp.13022
Corrêa, R., Gomez, G., Baulcombe, D. & Elena, SF. (2020) Viral fitness determines magnitude of transcriptomic and epigenomic reprograming… Mol. Biol. Evo. 37: 1866-81. DOI: 10.1093/molbev/msaa091
Sanz-Carbonell A., Marques, MC., Martinez, G. & Gomez, G. (2020) Dynamic architecture and implications of the miRNA network underlying the response to stress… RNA Biology 2: 292-308. DOI: 10.1080/15476286.2019.1697487.
Marquez-Molins, J., Navarro, J.A., Pallas, V. and Gomez, G. (2019) Highly efficient construction of infectious viroid‐derived clones. Plant Methods 15: 87. DOI: 10.1186/s13007-019-0470-4
Cervera, L., Marques, M., Sanz-Carbonell, A., Marquez-Molins, J., Carbonell, A., Daros, JA. and Gomez, G. (2019) Identification and characterization of a stress-responsive TAS3-derived tasiRNAs in melon. Plant and Cell Physiology 60: 2382-2393. DOI: 10.1093/pcp/pcz131.
Sanz Carbonell, A., Marques, MC., Bustamante, A., Fares, MA., Rodrigo, G. and Gomez, G. (2019). Inferring the miRNA-mediated regulatory network of response to stress in melon. BMC Plant Biology 19:78. DOI: 10.1186/s12870-019-1679-0
Bustamante, A., Marques, MC., Sanz Carbonell, A. and G. Gomez. (2018). Alternative processing of its precursor is related to miR319 decreasing in plants exposed to cold. Scientific Reports 8(1): 15538. DOI:10.1038/s41598-018-34012-7
Owens, RA., Gómez, G., Lisón, P., Conejero, V. (2017) Changes in the host proteome and transcriptome induced by viroid infection. In Viroids and Plant-virus Satellites – Hadidi, Randles, Flores, and Palukaitis (Ed), Elsevier. 105-112. ISBN: 9780128014981
Castellano M., Martinez G., Marques MC., Moreno J., Köhler C., Pallas V. & Gomez G. (2016). Changes in the DNA methylation of the host male gametophyte of viroid-infected cucumber. Jounal of Experimental Botany 67: 5857-5868. DOI: 10.1093/jxb/erw353
Castellano, M.; Pallás, V. and Gómez, G. (2016). A pathogenic long noncoding RNA redesigns the epigenetic landscape of infected cells by subverting host Histone Deacetylase 6 activity. New Phytologist 211: 1311-1322. DOI: 10.1111/nph.14001
Castellano M, Martinez G, Pallas V and Gomez G. (2015). Alterations in host-DNA methylation in response to expression of HSVd in N. benthamiana. Plant Pathology 64: 1247-1257. DOI: 10.1111/ppa.12358
Martinez G, Castellano M, Tortosa M, Pallas V and Gomez G. (2014). A pathogenic ncRNA induces changes in dynamic DNA methylation of rRNA genes in host plants. Nucleic Acids Research 42: 1553-1562. DOI: 10.1093/nar/gkt968
Funding
Current funding
Former funding
Spanish Ministry of Economy (I+D Retos, 2016-2018) – AGL2016-79825-R.
CSIC (Intramural, 2016-2017).
Spanish Ministry of Economy (Explora, 2015-2016).
SENECYT–Ecuador (Program PROMETEO 2013-2015)
Generalitat Valenciana (Grupos emergentes, 2013-2014).