Regulatory Networks

At ncRNA-lab we are interested in deciphering the regulatory pathways mediated by non coding RNAs (mainly small ncRNAs) for a better understanding of the molecular mechanisms that allow crops to respond and eventually adapt to biotic and abiotic stress conditions.

Research lines

Regulatory networks of response to stress mediated by miRNAs

In general, plants respond to changes in environmental conditions through a complex transcriptional reprogramming…

Differential processing of miRNAs in response to stress

miRNAs are fundamental endogenous regulators of gene expression in higher organisms. miRNAs modulate multiple biological processes…

Viroids-host interactions

Viroids are a class of sub-viral plant-pathogenic long noncoding RNAs (240-400 nt) composed of a circular single-stranded molecule. Viroid infection comprises a series of coordinated steps involving…

Epigenetic regulation of the plant-environment interplay

Eukaryotic organisms exposed to adverse conditions are required to show a certain degree of transcriptional plasticity in order…




Gustavo Germán Gómez

Gustavo Germán Gómez

CSIC Scientific Researcher
(+34) 963544777

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Gustavo Germán Gómez

Gustavo Germán Gómez

CSIC Scientific Researcher
(+34) 963544777

+ info

Postdoctoral Researchers

Francesca Longo

Plant-PREDICTOR Project
Tel: 34 963543996

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María Carmen Herranz Gordo

BotVid-SENSOR Project
Tel: 34 963543996

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PhD Students

Julia Corell Sierra

Predoctoral contract, GVA (ACIF)
(+34) 963544783

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Gabriela Hernández Azurdia

Predoctoral contract, GVA (ACIF)
(+34) 963544783

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Pascual Villalba Bermell

Predoctoral contract, AEI
(+34) 963544783

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Technical assitant

Cristina Atienza
Tel: 34 963543996

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Miguel Ruiz Ibañez

Tel: 34 963543996

Antonio Gonzalez Sanchez

TFM Bioinformatics UV
Tel: 34 963543996

Elisa Soriano Perez

TFG Biotechnology UCV
Tel: 34 963543996

Sergei Yurievich

External Practices UV
Tel: 34 963543996

Aleksandra Ruzic

External Practices UV
Tel: 34 963543996

Former lab members
Joan Marquez-Molins

María Carmen Marques-Romero

Antonio Bustamante

Alejandro Sanz-Carbonell


Current projects

Past projects


Relevant Publications
(last ten years)

Márquez-Molins, J., Villalba-Bermell, P., Corell-Sierra, J., Pallás, V. & Gomez, G. (2023) Integrative time scale and multi omics analysis of host responses to Viroid infection. Plant, Cell & Environment, 119. DOI: 10.1111/pce.14647.

Márquez-Molins J, Juarez-Gonzalez VT, Gomez G, Pallas V, Martinez G. (2022). Occurrence of RNA post-transcriptional modifications in plant viruses and viroids and their correlation with structural and functional features. Virus Res. DOI: 10.1016/j.virusres.2022.198958.

Marquez-Molins J., Hernandez-Azurdia A.G., Urrutia-Perez M., Pallas V. and Gomez G. (2022). A circular RNA vector for targeted plant gene silencing based on an asymptomatic viroid. The Plant Journal. DOI: 10.1111/tpj.15929.

Gómez G., Marquez-Molins J., Martinez G. and Pallas V. (2022) Plant epigenome alterations: an emergent player in viroid-host interactions. Virus Res. 318:198844. DOI: 10.1016/j.virusres.2022.198844.

Marqués MC., Sánchez-Vicente J., Ruiz R., Montagud-Martínez R., Márquez-Costa R., Gómez G., Carbonell A., Daròs JA. and Rodrigo G. (2022) Diagnostics of Infections Produced by the Plant Viruses TMV, TEV, and PVX with CRISPR-Cas12 and CRISPR-Cas13. ACS Synth Biol. DOI: 10.1021/acssynbio.2c00090.

Villalba-Bermell P., Marquez-Molins J., Marques MC., Corell-Sierra J., Hernandez-Azurdia AG., Pico B., Monforte AJ., Elena SF., Gomez G. (2021) Combined stress conditions in melon induce non-additive effects in the core miRNA regulatory network. Front. Plant Sci. 12:769093. DOI: 10.3389/fpls.2021.769093

Marquez-Molins J, Navarro JA, Seco LC, Pallas V, Gomez G. (2021) Might exogenous circular RNAs act as protein-coding transcripts in plants? RNA Biol. 14:1-10. DOI: 10.1080/15476286.2021.1962670

Vázquez-Prol F, Márquez-Molins J, López-Gresa MP, Bellés JM, Gomez G, Pallás V, Lisón P. (2021) Symptom Severity, Infection Progression and Plant Responses in Solanum Plants Caused by Three Pospiviroids… Int. J. Mol. Sci. 22: 6189. DOI: 10.3390/ijms2212618

Marquez-Molins, J., Gomez G., Pallas V. (2020) Hop stunt viroid: a polyphagous pathogenic RNA that has shed light on viroid-host interactions. Mol. Plant. Pathology. DOI: 10.1111/mpp.13022

Corrêa, R., Gomez, G., Baulcombe, D. & Elena, SF. (2020) Viral fitness determines magnitude of transcriptomic and epigenomic reprograming… Mol. Biol. Evo. 37: 1866-81. DOI: 10.1093/molbev/msaa091

Sanz-Carbonell A., Marques, MC., Martinez, G. & Gomez, G. (2020) Dynamic architecture and implications of the miRNA network underlying the response to stress… RNA Biology 2: 292-308. DOI: 10.1080/15476286.2019.1697487.

Marquez-Molins, J., Navarro, J.A., Pallas, V. and Gomez, G. (2019) Highly efficient construction of infectious viroid‐derived clones. Plant Methods 15: 87. DOI: 10.1186/s13007-019-0470-4

Cervera, L., Marques, M., Sanz-Carbonell, A., Marquez-Molins, J., Carbonell, A., Daros, JA. and Gomez, G. (2019) Identification and characterization of a stress-responsive TAS3-derived tasiRNAs in melon. Plant and Cell Physiology 60: 2382-2393. DOI: 10.1093/pcp/pcz131.

Sanz Carbonell, A., Marques, MC., Bustamante, A., Fares, MA., Rodrigo, G. and Gomez, G. (2019). Inferring the miRNA-mediated regulatory network of response to stress in melon. BMC Plant Biology 19:78. DOI: 10.1186/s12870-019-1679-0

Bustamante, A., Marques, MC., Sanz Carbonell, A. and G. Gomez. (2018). Alternative processing of its precursor is related to miR319 decreasing in plants exposed to cold. Scientific Reports 8(1): 15538. DOI:10.1038/s41598-018-34012-7

Owens, RA., Gómez, G., Lisón, P., Conejero, V. (2017) Changes in the host proteome and transcriptome induced by viroid infection. In Viroids and Plant-virus Satellites – Hadidi, Randles, Flores, and Palukaitis (Ed), Elsevier. 105-112. ISBN: 9780128014981

Castellano M., Martinez G., Marques MC., Moreno J., Köhler C., Pallas V. & Gomez G. (2016). Changes in the DNA methylation of the host male gametophyte of viroid-infected cucumber. Jounal of Experimental Botany 67: 5857-5868. DOI: 10.1093/jxb/erw353

Castellano, M.; Pallás, V. and Gómez, G. (2016). A pathogenic long noncoding RNA redesigns the epigenetic landscape of infected cells by subverting host Histone Deacetylase 6 activity. New Phytologist 211: 1311-1322. DOI: 10.1111/nph.14001

Castellano M, Martinez G, Pallas V and Gomez G. (2015). Alterations in host-DNA methylation in response to expression of HSVd in N. benthamiana. Plant Pathology 64: 1247-1257. DOI: 10.1111/ppa.12358

Martinez G, Castellano M, Tortosa M, Pallas V and Gomez G. (2014). A pathogenic ncRNA induces changes in dynamic DNA methylation of rRNA genes in host plants. Nucleic Acids Research 42: 1553-1562. DOI: 10.1093/nar/gkt968


Current funding

Former funding

Spanish Ministry of Economy (I+D Retos, 2016-2018) – AGL2016-79825-R.

CSIC (Intramural, 2016-2017).

Spanish Ministry of Economy (Explora, 2015-2016).

SENECYT–Ecuador (Program PROMETEO 2013-2015)

Generalitat Valenciana (Grupos emergentes, 2013-2014).