Regulatory Networks

Welcome New Members to Our Lab Team!

We are pleased to introduce three new members joining our laboratory: Samanta, a PhD student under contract with the Santiago Grisolía Program (GVA), brings a strong research drive to our team. Vega joins us as a lab technician, providing valuable technical support....

ncRNA lab is awarded at CV+i Circular Day for its AgroSENSING project

We're excited to share that the ncRNA Lab team has reached a significant milestone by receiving the "Unincorporated Business" Startup competition award at this year's CV+i Circular Day event. This recognition acknowledges their pioneering efforts in developing the...

ncRNA lab participates in the Grapedia Annual Meeting

Last September 12th, our PhD student Pascual Villalba participated in the Grapedia Annual Meeting, an innovative portal to integrate knowledge, resources and services for the grape scientific community and industry, held in Valencia at the Botanical Garden of the...

A fully funded PhD position is available in the ncRNAlab

Are you interested in deciphering the ncRNA-mediated mechanisms regulating plant-environment interaction?  The ncRNAlab offers a PhD position (4 years). We search graduates in biology/biotechnology or similar fascinated by the Systems Biology.Do not hesitate to...

Congratulations to Our Team Member on Successfully Presenting his Master’s Thesis!

We are thrilled to extend our warmest congratulations to one of our esteemed team members, Antonio González, on the successful presentation of his Master's thesis! This remarkable achievement is a testament to their dedication, hard work, and passion for research. As...

Our project “GLOBAL-REPaIr” has successfully received funding in the recent call of the “National Research Agency”

Our project “GLOBAL-REPaIr” has successfully received funding in the recent call of the “National Research Agency” (AEI). Additionally, we have been granted with a PhD student contract.For three years more of very exiting work understanding the regulation of the...

CSIC encourages young researchers with the JAE Intro grant

From ncRNAlab we appreciate the contribution of the Spanish National Research Council (Spanish: Consejo Superior de Investigaciones Científicas, CSIC) to the development of young scientists through initiatives such as the JAE Intro grant and we congratulate our...

The biotechnological innovation developed by the ncRNAlab has been awarded

Our pioneering project, «AGROSENSING,» aimed at establishing a technology-driven company, has been chosen to participate in the prestigious LLAMP Tech Transfer mentoring program.

The ncRNAlab participates in EXPOCIENCIA

The past, May 6th the PhD students Gabriela Hernandez and Miguel Ruiz, have participated in representation of the ncRNAlab in the XV edition of EXPOCIENCIA in the Parc Cientific of the University of Valencia.

A ncRNAlab project is included in the AGROTECUV program

The Plant-PREDICTOR innovation project of the ncRNAlab at I2SysBio has been awarded in the framework of the call of the program to attract innovative business projects linked to the agri-food sector of the high-tech incubator in sustainable agri-food AgrotecUV

At ncRNA-lab we are interested in decipher the regulatory pathways mediated by non coding RNAs (mainly small ncRNAs) for a better understanding of the molecular mechanisms that allow crops to respond and eventually adapt to biotic and abiotic stress conditions.

Research lines

Regulatory networks of response to stress mediated by miRNAs

In general, plants respond to changes in environmental conditions through a complex transcriptional reprogramming…

Differential processing of miRNAs in response to stress

miRNAs are fundamental endogenous regulators of gene expression in higher organisms. miRNAs modulate multiple biological processes…

Viroids-host interactions

Viroids are a class of sub-viral plant-pathogenic long noncoding RNAs (240-400 nt) composed of a circular single-stranded molecule. Viroid infection comprises a series of coordinated steps involving…

Epigenetic regulation of the plant-environment interplay

Eukaryotic organisms exposed to adverse conditions are required to show a certain degree of transcriptional plasticity in order…



Gustavo Germán Gómez

Gustavo Germán Gómez

CSIC Scientific Researcher
(+34) 963544777

+ info

Postdoctoral Researchers

Francesca Longo

Plant-PREDICTOR Project
Tel: 34 963543996

+ info

María Carmen Herranz Gordo

BotVid-SENSOR Project
Tel: 34 963543996

+ info

PHD Students

Julia Corell Sierra

Contract PTI Salud Global CSIC
(+34) 963544783

+ info

Gabriela Hernández Azurdia

Predoctoral contract, GVA (ACIF)
(+34) 963544783

+ info

Pascual Villalba Bermell

Predoctoral contract, GVA (ACIF)
(+34) 963544783

+ info

Technical assitant

Cristina Atienza
Tel: 34 963543996

+ info


Miguel Ruiz Ibañez

Tel: 34 963543996

Antonio Gonzalez Sanchez

TFM Bioinformatics UV
Tel: 34 963543996

Elisa Soriano Perez

TFG Biotechnology UCV
Tel: 34 963543996

Sergei Yurievich

External Practices UV
Tel: 34 963543996

Aleksandra Ruzic

External Practices UV
Tel: 34 963543996

Former lab members
Joan Marquez-Molins

María Carmen Marques-Romero

Antonio Bustamante

Alejandro Sanz-Carbonell


Current projects

Past projects


Relevant Publications
(last eight years)

Marquez-Molins J, Juarez-Gonzalez VT, Gomez G, Pallas V, Martinez G. (2022). Occurrence of RNA post-transcriptional modifications in plant viruses and viroids and their correlation with structural and functional features. Virus Res. doi: 10.1016/j.virusres.2022.198958.

Marquez-Molins J., Hernandez-Azurdia A.G., Urrutia-Perez M., Pallas V. and Gomez G. (2022). A circular RNA vector for targeted plant gene silencing based on an asymptomatic viroid. The Plant Journal doi: 10.1111/tpj.15929.

Gómez G., Marquez-Molins J., Martinez G. and Pallas V. (2022) Plant epigenome alterations: an emergent player in viroid-host interactions. Virus Res. 318:198844. doi: 10.1016/j.virusres.2022.198844..

Marqués MC., Sánchez-Vicente J., Ruiz R., Montagud-Martínez R., Márquez-Costa R., Gómez G., Carbonell A., Daròs JA. and Rodrigo G. (2022) Diagnostics of Infections Produced by the Plant Viruses TMV, TEV, and PVX with CRISPR-Cas12 and CRISPR-Cas13. ACS Synth Biol. doi: 10.1021/acssynbio.2c00090.

Villalba-Bermell P., Marquez-Molins J., Marques MC., Corell-Sierra J., Hernandez-Azurdia AG., Pico B., Monforte AJ., Elena SF., Gomez G. (2021) Combined stress conditions in melon induce non-additive effects in the core miRNA regulatory network. Front. Plant Sci. 12:769093. DOI: 10.3389/fpls.2021.769093

Marquez-Molins J, Navarro JA, Seco LC, Pallas V, Gomez G. (2021) Might exogenous circular RNAs act as protein-coding transcripts in plants? RNA Biol. 14:1-10. DOI: 10.1080/15476286.2021.1962670

Vázquez-Prol F, Márquez-Molins J, López-Gresa MP, Bellés JM, Gomez G, Pallás V, Lisón P. (2021) Symptom Severity, Infection Progression and Plant Responses in Solanum Plants Caused by Three Pospiviroids… Int. J. Mol. Sci. 22: 6189. DOI: 10.3390/ijms2212618

Marquez-Molins, J., Gomez G., Pallas V. (2020) Hop stunt viroid: a polyphagous pathogenic RNA that has shed light on viroid-host interactions. Mol. Plant. Pathology. DOI: 10.1111/mpp.13022

Corrêa, R., … Gomez G., Baulcombe, D. & Elena, SF. (2020) Viral fitness determines magnitude of transcriptomic and epigenomic reprograming… Mol. Biol. Evo. 37: 1866-81. DOI: 10.1093/molbev/msaa091

Sanz-Carbonell A., Marques, MC., Martinez, G. & Gomez, G. (2020) Dynamic architecture and implications of the miRNA network underlying the response to stress… RNA Biology 2: 292-308. DOI: 10.1080/15476286.2019.1697487.

Marquez-Molins, J., Navarro, J.A., Pallas, V. and Gomez, G. (2019) Highly efficient construction of infectious viroid‐derived clones. Plant Methods 15: 87 (DOI: 10.1186/s13007-019-0470-4)

Cervera, L., Marques, M., Sanz-Carbonell, A., Marquez-Molins, J., Carbonell, A., Daros, JA. and Gomez, G. (2019) Identification and characterization of a stress-responsive TAS3-derived tasiRNAs in melon. Plant and Cell Physiology 60: 2382-2393. DOI: 10.1093/pcp/pcz131.

Sanz Carbonell, A., Marques, MC., Bustamante, A., Fares, MA., Rodrigo, G. and Gomez, G. (2019). Inferring the miRNA-mediated regulatory network of response to stress in melon. BMC Plant Biology 19:78.

Bustamante, A., Marques, MC., Sanz Carbonell, A. and G. Gomez. (2018). Alternative processing of its precursor is related to miR319 decreasing in plants exposed to cold. Scientific Reports 8(1): 15538.

Owens, RA., Gómez, G., Lisón, P., Conejero, V. (2017) Changes in the host proteome and transcriptome induced by viroid infection. In Viroids and Plant-virus Satellites – Hadidi, Randles, Flores, and Palukaitis (Ed), Elsevier. 105-112.

Castellano M., Martinez G., Marques MC., Moreno J., Köhler C., Pallas V. & Gomez G. (2016). Changes in the DNA methylation of the host male gametophyte of viroid-infected cucumber. Jounal of Experimental Botany 67: 5857-5868.

Castellano, M.; Pallás, V. and Gómez, G. (2016). A pathogenic long noncoding RNA redesigns the epigenetic landscape of infected cells by subverting host Histone Deacetylase 6 activity. New Phytologist 211: 1311-1322.

Castellano M, Martinez G, Pallas V and Gomez G. (2015). Alterations in host-DNA methylation in response to expression of HSVd in N. benthamiana. Plant Pathology 64: 1247-1257

Martinez G, Castellano M, Tortosa M, Pallas V and Gomez G. (2014). A pathogenic ncRNA induces changes in dynamic DNA methylation of rRNA genes in host plants. Nucleic Acids Research 42: 1553-1562.


Current funding

Former funding

Spanish Ministry of Economy (I+D Retos, 2016-2018) – AGL2016-79825-R.

CSIC (Intramural, 2016-2017).

Spanish Ministry of Economy (Explora, 2015-2016).

SENECYT–Ecuador (Program PROMETEO 2013-2015)

Generalitat Valenciana (Grupos emergentes, 2013-2014).